Morphological examination of the blood and sternal marrow on nine patients treated with thiouracil.

Sternal marrow studies in thyrotoxicosis treated with thiouracil and review of literature regarding thiouracil effects on blood.

A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...

The effect of thiouracil on leukemia.

By LOUIS R. LIMARZI, M.D., RICHARD J. KULASAVAGE, M.D., AND CONRAD L. PIRANI, M.D. O NE of the toxic reactions of therapeutic doses of thiouracilt in the treatment of hyperthyroidism is the development of granulocytopenia. A nonfatal granulocytopenia and a fatal type of agranulocytosis have been reported. The selective action of thiouracil on the granulopoietic tissue is the basis for the prese...

Some Observations on Thiouracil Neutropenia, with Special Reference to the Sternal Marrow.

Utility of F-18 FDG PET/CT for Detection of Bone Marrow Metastases in Prostate Cancer Patients Treated with Radium-223

A 76-year-old man with symptomatic bone metastases from castrationresistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or rel...

Beware of Bone Marrow: Incidental Detection and Primary Diagnosis of Solid Tumours in Bone Marrow Aspiration and Biopsies; A Study of 22 Cases

Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current...